Metropolitan Police Commissioner Dame Cressida Dick is leaving her role after a series of damaging controversies.
Dame Cressida said she had been left with “no choice” after London Mayor Sadiq Khan made it clear to her he had no confidence in her leadership.
Last week, the police watchdog found “disgraceful” misogyny, discrimination, and sexual harassment among some Met PCs.
Dame Cressida, the first woman to lead the biggest UK police force, also faced criticism over the Sarah Everard case.
Her conduct was referenced in an independent report that accused the force of institutional corruption over the unsolved murder of Daniel Morgan, and before she became commissioner she was in charge of the operation that led to the fatal shooting of Jean Charles de Menezes.
Speaking on BBC London hours before her departure was announced, she insisted that she had “absolutely no intention” of quitting and that she was “seething angry” about the police watchdog’s findings into the culture at Charing Cross police station.
But in his statement, Mr. Khan said he was “not satisfied” with Dame Cressida’s response and that she “will be stepping aside” as a result.
Mr. Khan thanked the commissioner for her 40-year policing career.
He said he would now “work closely with the home secretary on the appointment of a new commissioner” with an aim to restore trust in the Met.
Prime Minister Boris Johnson said Dame Cressida “has served her country with great dedication and distinction over many decades”.
Home Secretary Priti Patel said the police chief held the role “during challenging times” and that she “exemplified the increasingly diverse nature of our police”.
Labour’s shadow home secretary Yvette Cooper thanked Dame Cressida for her public service and said reform was needed to rebuild public confidence after recent cases.
Lib Dem leader Sir Ed Davey said a change in the force’s leadership was “long overdue”.
He added that Boris Johnson, whose part in the Downing Street parties held during lockdown is still being investigated by the Met, must have no role in choosing her successor.
Harvey Proctor, a former MP falsely accused of murder during a disastrous probe into claims of a VIP paedophile ring, said her departure had come not a “day too soon” and called for a full inquiry into all her “personal mistakes”.
Alastair Morgan, who has spent decades campaigning for justice for his brother Daniel after he was killed with an axe in a pub car park in south-east London in the 1980s, said Dame Cressida had “disappointed” his family on every level during her time in charge.
“Although I think it is a shame that we are seeing another commissioner disappear under a cloud of smoke, it is necessary,” he said.